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Seminar Peter Kramar

On January 9, 2020

Planar lipid bilayer as model of cell membrane exposed to electric field P. Kramar, Univ of Ljubljana

Peter Kramar

Peter Kramar

The application of pulsed electric fields to biological cells has emerged as a powerful technique for manipulation of cell membrane permeability, with wide-ranging use in biomedical and biotechnological applications. Pulsed electric field (i.e. applied electric pulses), induces local distortions and structural rearrangements of lipid molecules in the cell membrane. As a result, the membrane becomes transiently permeable even after the external field is removed, allowing otherwise impermeant molecules to cross the membrane and reach the cytosol. This phenomenon is often referred to as electroporation or electropermeabilization. Experimentally formed planar lipid bilayers can be considered to be a small model of a cell membrane assembled in laboratory
conditions It is often used to study electroporation phenomena because it is electrically accessed from both sides and can be represented by an electrical model of resistor and capacitor wired in parallel. The measured results can be compared to Molecular Dynamics simulation studies of planar lipid bilayers.
Type :
Seminars and conferences
Place(s) :
Cachan Campus
Amphi Chemla, Institut d'Alembert

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