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Institut d'Alembert Seminar - Anne IMBERTY

On November 29, 2022
10h30 : Welcome coffee, Espace Simondon, 1E29
11h :  Talk by Anne Imberty

The Institut d'Alembert will welcome Anne Imberty, CNRS Research Director at the Plant Macromolecular Research Center in Grenoble, to give a seminar "Pathogèns lectins : from structural glycobiology to antiadhesive strategies"

Presentation :

A large number of pathogenic microorganisms display receptors for specific recognition and adhesion to the glycoconjugates present on human tissues. In addition to membrane-bound adhesins, soluble lectins are involved in lung infections caused by the bacteria Pseudomonas aeruginosa and Burkholderia cepacia and by the fungus Aspergillus fumigatus that are responsible for hospital-acquired diseases. The multivalency of lectin is proposed to play a role in their strong avidity for glycosylated cell surfaces, their specific binding to targeted human tissues, and also in their ability to affect membrane dynamics by clustering glycosphingolipids, resulting in some cases in internalization of intracellular pathogens. Accumulated knowledge about the structures of the lectins and the interactions with host glycoconjugates has led to the design of powerful glyco-derived inhibitors that can serve as antimicrobial therapeutic agents, as a complement to or an alternative to antibiotic therapy. Several strategies are developed with development of glycoderivatives and/or multivalent glycostructures. The structural role of calcium present in the binding site of fucose and galactose specific lectins has been investigated through x-ray and neutron crystallography (1). Novel inhibition strategy with non-carbohydrate glycomimetics is now proposed (2).
Type :
Seminars and conferences
Place(s) :
Ens Paris Saclay - Amphi Simondon - 1B26-South-West Building

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